Histamine Intolerance and Gut Health – What You Need to Know

Article published at: 25. mar 2025 Article author: Shahram Lavasani Article tag: Histamine
Histamine Intolerance and Gut Health
All Gut Wellness Blog

Do you often experience unexplained symptoms like headaches, rashes, fatigue, or nasal congestion after eating certain foods? You might be one of many individuals dealing with histamine intolerance—a condition that is often misunderstood and misdiagnosed.

Although it shares symptoms with allergies, histamine intolerance is not an allergy. Instead, it occurs when your body lacks enough of the enzyme diamine oxidase (DAO), which is responsible for breaking down histamine in the digestive tract. When histamine accumulates in the body faster than it can be degraded, it may trigger a wide range of symptoms.

It is your immune system that produces Histamine

Histamine is a naturally occurring compound produced by the immune system. Its main role is to initiate an inflammatory response—a vital part of your body’s defense mechanism. However, when too much histamine is present, the immune response can become exaggerated, resulting in reactions such as:

  •    Skin itching or hives
  •     Eczema
  •     Headaches or migraines
  •     Nasal congestion or runny nose
  •     Shortness of breath
  •     Fatigue
  •     Digestive discomfort
  •     Effects on the central nervous system (CNS), such as brain fog or irritability

Certain foods are known to contain high levels of histamine, including red wine, aged cheese, smoked fish, salami, and leftover foods. Even some fruits and vegetables may contribute. For individuals with DAO deficiency or heightened histamine sensitivity, these foods can cause significant discomfort.

Gut Health and Histamine – The Missing Link

Histamine intolerance is more common among individuals with gastrointestinal issues like IBS (Irritable Bowel Syndrome), Crohn’s disease, or mast cell-related disorders. These conditions often disrupt the gut lining and microbial balance, making it harder for the body to manage the histamine levels.

Also, another lesser-known source of histamine, is some Probiotic supplements (but not GutMagnific😊.

Some probiotic strains can actually produce histamine, which could worsen symptoms for those that are already sensitive.

GutMagnific is a histamine-free probiotic

 If you’re looking to support your gut health without triggering histamine reactions, GutMagnific is a safe option. Unlike many probiotics, GutMagnific has been thoroughly researched and genetically analysed to ensure none of its five clinically selected Lactobacillus strains produce histamine.

Developed by a scientific team in Lund with over 20 years of expertise in immunology, microbiology, and medical research, GutMagnific is designed to:

Restore microbial balance in the gut

Balance the immune system by activating anti-inflammatory immune cells

Strengthen the intestinal barrier for improved resilience and digestion

This precision-formulated probiotic is particularly suitable for individuals with IBS and histamine sensitivity, and offers gentle support for gut health — without adding to the histamine burden.

Managing histamine intolerance starts with awareness — knowing which foods to avoid and how to support your body naturally. Choosing the right probiotic can make a real difference. With GutMagnific, you can nurture your microbiome, balance the immune system, and reduce the risk of histamine-related flare-ups.

Gut health is central to overall wellness — and with the right tools, it’s possible to feel better from the inside out.

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